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Download Actin-based Motility: Cellular, Molecular and Physical by J. Victor Small, Klemens Rottner (auth.), Marie-France PDF

By J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)

This e-book offers the mobile, molecular and actual elements of strength and move through the self-assembly of actin, essentially the most considerable proteins present in cells, into cytoskeletal filaments. « Actin-based motile tactics » are liable for a wide number of motile actions reminiscent of chemotactic locomotion, embryonic and metastatic phone migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic procedures together with, axis patterning in early embryos, axonal progress in mind improvement, and the immune reaction and synaptic plasticity procedures on the foundation of studying and reminiscence. The booklet describes how the lately undertaken multidisciplinary and multiscale techniques have explored the molecular and actual mechanisms on the foundation of strength and flow produced by way of actin self-assembly. the selected issues express how advances were made within the box of phone motility as a result of the development in reside mobile imaging, mild microscopy, superior answer within the constitution of huge protein assemblies, the biochemical research and mathematical modeling of actin meeting dynamics and the advance of nanotechnologies permitting us to degree forces within the variety of pico- to nano-newtons produced through actin assemblies.

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Extra resources for Actin-based Motility: Cellular, Molecular and Physical Aspects

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P. Newsome, S. Schleich, and M. Way. 2009. The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Nature. 458: 87–91. , and V. Niggli. 2001. The Rho/Rho-kinase and the phosphatidylinositol 3-kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells. Int J Cancer. 91:763–71. , and P. Martin. 2002. Structures in focus--filopodia. Int J Biochem Cell Biol. 34:726–30. A. D. Pollard. 1975. Evidence for biased bidirectional polymerization of actin filaments using heavy meromyosin prepared by an improved method.

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2006. Staying in shape with formins. Dev Cell. 10:693–706. , and K. Rottner. 2006. The making of filopodia. Curr Opin Cell Biol. 18:18–25. , J. Chou, H. Falet, R. H. P. Stossel. 2001. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 155:511–17. C. 2004. Newest findings on the oldest oncogene; how activated src does it. J Cell Sci. 117:989–98. J. E. Bear, J. B. S. Sechi. 2002. Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization.

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