By Alan Ebringer
Ankylosing spondylitis and Klebsiella is a finished and informative textual content at the reason for Ankylosing spondylitis. Ankylosing spondylitis (AS) is a which impacts 20 million humans all over the world and is probably going brought on or initiated by means of a bowel an infection from Klebsiella bacteria.
When a sufferer is contaminated via Klebsiella bacteria, his or her immune process will make antibodies opposed to all of the antigens or molecules present in the microbe. simply because a number of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but in addition the self tissues corresponding to the joints and the cells having a similar HLA molecules, that is how the sickness AS starts off. this can be the concept that of molecular similarity or “molecular mimicry” which formerly has been discovered to paintings in different autoimmune ailments; rheumatic fever and rheumatoid arthritis.
The first paper in this topic was once released in 1976 and because thenover a hundred papers on rheumatological issues were released, from Prof Ebringer’s workforce, on the department of existence Sciences, King’s collage in London, united kingdom.
The appropriate info from those papers is extracted and offered during this ebook structure making it available to wellbeing and fitness execs, examine associations, pharmaceutical businesses and universities and most of the people.
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Extra resources for Ankylosing spondylitis and Klebsiella
1988;27 Suppl 2:6–11. Khan M. A worldwide overview: the epidemiology of HLA-B27 and associated spondyloarthritides. In: Calin A, Taurog JD, editors. The spondyloarthritides. Oxford: Oxford University Press; 1998. p. 17–26. Schlosstein L, Terasaki PI, Bluestone R, Pearson CM. High association of an HLA antigen W27, with ankylosing spondylitis. N Engl J Med. 1973;288:704–6. 1 Introduction: The Problem of HLA-B27 in Ankylosing Spondylitis Many diseases are associated with HLA antigens. For instance, rheumatoid arthritis is found more frequently in individuals possessing HLA-DR1 and HLA-DR4 antigens.
Antigenic crossreaction between host and parasite as a possible cause of pathogenicity. Nature. 1962;193:151–4. Whittingham S, Mackay IR. Tissue antigens: autoantigens, alloantigens xenoantigens and neoantigens. Aust N Z J Med. 1977;7:172–94. 1 Introduction: Involvement of Muscle Pathology in Ankylosing Spondylitis Ankylosing spondylitis patients attending the ‘Ankylosing Spondylitis Research Clinic of the Middlesex Hospital’ complained frequently of muscle stiffness and pain. Some even mentioned that there was never any day that they felt to be free of pain or stiffness.
4 Haemagglutination Method Sheep erythrocytes coated with Klebsiella lipopolysaccharide (LPS) were prepared and assay carried out as previously described. The titre of each typing serum was expressed as the log2 difference between the titre achieved with coated cells compared to the titre obtained with uncoated cells. 3 × 1013 microorganisms), ultrasonicated and centrifuged. Supernatant was filtered through Sephadex G-25 and 125I-labelling of Klebsiella sonicate preparation, carried out as previously described.